Hypercalciuria increases the risk for urolithiasis, but renal adaptive mechanisms reduce this
risk. For example, transient receptor potential vanilloid 5 knockout (TPRV5−/−) mice lack
kidney stones despite urinary calcium (Ca 2+) wasting and hyperphosphaturia, perhaps as a
result of their significant polyuria and urinary acidification. Here, we investigated the
mechanisms linking hypercalciuria with these adaptive mechanisms. Exposure of dissected
mouse outer medullary collecting ducts to high (5.0 mM) extracellular Ca 2+ stimulated H+ …