Monocyte chemotactic protein-1 and its role in insulin resistance
H Sell, J Eckel - Current opinion in lipidology, 2007 - journals.lww.com
H Sell, J Eckel
Current opinion in lipidology, 2007•journals.lww.comMonocyte chemotactic protein-1 is an adipokine with insulin-resistance-inducing capacity
that is related to increased adipose tissue mass in obesity and insulin resistance. It plays an
important role in adipose tissue inflammation by recruiting macrophages into fat. Monocyte
chemotactic protein-1 is thus a therapeutic target, and may represent an important factor
linking adipose tissue inflammation, obesity and type 2 diabetes.
that is related to increased adipose tissue mass in obesity and insulin resistance. It plays an
important role in adipose tissue inflammation by recruiting macrophages into fat. Monocyte
chemotactic protein-1 is thus a therapeutic target, and may represent an important factor
linking adipose tissue inflammation, obesity and type 2 diabetes.
Summary
Monocyte chemotactic protein-1 is an adipokine with insulin-resistance-inducing capacity that is related to increased adipose tissue mass in obesity and insulin resistance. It plays an important role in adipose tissue inflammation by recruiting macrophages into fat. Monocyte chemotactic protein-1 is thus a therapeutic target, and may represent an important factor linking adipose tissue inflammation, obesity and type 2 diabetes.
Lippincott Williams & Wilkins