SLAM receptors and SAP influence lymphocyte interactions, development and function

PL Schwartzberg, KL Mueller, H Qi… - Nature Reviews …, 2009 - nature.com
PL Schwartzberg, KL Mueller, H Qi, JL Cannons
Nature Reviews Immunology, 2009nature.com
Mutations that affect the adaptor molecule SLAM-associated protein (SAP) underlie the
primary immunodeficiency disease X-linked lymphoproliferative syndrome. SAP is required
for mediating signals from members of the signalling lymphocytic activation molecule
(SLAM) family of immunomodulatory receptors. Recent data have highlighted a role for SAP
in the development of innate-like T-cell lineages, including natural killer T cells, and in the
regulation of the interactions between B cells and T cells that are required for germinal …
Abstract
Mutations that affect the adaptor molecule SLAM-associated protein (SAP) underlie the primary immunodeficiency disease X-linked lymphoproliferative syndrome. SAP is required for mediating signals from members of the signalling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors. Recent data have highlighted a role for SAP in the development of innate-like T-cell lineages, including natural killer T cells, and in the regulation of the interactions between B cells and T cells that are required for germinal-centre formation and long-term humoral immunity. These data have revealed that SLAM family members and SAP have crucial roles in regulating lymphocyte interactions and adhesion, which are required for the normal development, homeostasis and function of the immune system.
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