CXCR4 and mobilization of hematopoietic precursors
MP Rettig, P Ramirez, B Nervi, JF DiPersio - Methods in enzymology, 2009 - Elsevier
The binding of the chemokine [C‐X‐C motif] ligand 12 (CXCL12 or stromal cell–derived
factor 1α [SDF‐1α]) constitutively produced by bone marrow stromal cells and osteoblasts, to
the CXC receptor (CXCR) 4, a transmembrane chemokine receptor expressed on
hematopoietic stem and progenitor cells (HSPCs), has emerged as a key signal for HSPC
trafficking to and from the bone marrow. Disruption of CXCL12/CXCR4 signaling causes
leukocytosis, with the release of HSPCs, neutrophils, and lymphocytes into the peripheral …
factor 1α [SDF‐1α]) constitutively produced by bone marrow stromal cells and osteoblasts, to
the CXC receptor (CXCR) 4, a transmembrane chemokine receptor expressed on
hematopoietic stem and progenitor cells (HSPCs), has emerged as a key signal for HSPC
trafficking to and from the bone marrow. Disruption of CXCL12/CXCR4 signaling causes
leukocytosis, with the release of HSPCs, neutrophils, and lymphocytes into the peripheral …