Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms.
Tumors that originate from pituitary somatotroph cells lead to aberrant secretion of growth
hormone and the distinctive features of acromegaly. This review discusses advances in the
understanding and treatment of acromegaly.