[HTML][HTML] The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
N Bonnet, KN Standley, EN Bianchi… - Journal of Biological …, 2009 - ASBMB
Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment
and adhesion and plays an important role in odontogenesis. In bone, periostin is
preferentially expressed in the periosteum, but its functional significance remains unclear.
We investigated Postn−/− mice and their wild type littermates to elucidate the role of
periostin in the skeletal response to moderate physical activity and direct axial compression
of the tibia. Furthermore, we administered a sclerostin-blocking antibody to these mice in …
and adhesion and plays an important role in odontogenesis. In bone, periostin is
preferentially expressed in the periosteum, but its functional significance remains unclear.
We investigated Postn−/− mice and their wild type littermates to elucidate the role of
periostin in the skeletal response to moderate physical activity and direct axial compression
of the tibia. Furthermore, we administered a sclerostin-blocking antibody to these mice in …