Primary immunodeficiencies: a field in its infancy
JL Casanova, L Abel - Science, 2007 - science.org
Science, 2007•science.org
A paradigm shift is occurring in the field of primary immunodeficiencies, with revision of the
definition of these conditions and a considerable expansion of their limits. Inborn errors of
immunity were initially thought to be confined to a few rare, familial, monogenic, recessive
traits impairing the development or function of one or several leukocyte subsets and
resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing
number of exceptions to each of these conventional qualifications have gradually …
definition of these conditions and a considerable expansion of their limits. Inborn errors of
immunity were initially thought to be confined to a few rare, familial, monogenic, recessive
traits impairing the development or function of one or several leukocyte subsets and
resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing
number of exceptions to each of these conventional qualifications have gradually …
A paradigm shift is occurring in the field of primary immunodeficiencies, with revision of the definition of these conditions and a considerable expansion of their limits. Inborn errors of immunity were initially thought to be confined to a few rare, familial, monogenic, recessive traits impairing the development or function of one or several leukocyte subsets and resulting in multiple, recurrent, opportunistic, and fatal infections in infancy. A growing number of exceptions to each of these conventional qualifications have gradually accumulated. It now appears that most individuals suffer from at least one of a multitude of primary immunodeficiencies, the dissection of which is helping to improve human medicine while describing immunity in natura.
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