Dissociated overexpression of cathepsin Dand estrogen receptor alpha in preinvasive mammary tumors
P Roger, JP Daubes, T Maudelonde, C Pignodel… - Human pathology, 2000 - Elsevier
The role of estrogen as a promoter agent of sporadic breast cancer has been considered by
assaying, in benign breast disease (BBD) and in situ carcinomas (CIS), 2 markers, the
estrogen receptor α (ERα) and cathepsin D (cath-D) involved in estrogen action on
mammary tissue. ERα and cath-D were assayed by quantitative immunohistochemistry
using an image analyzer in 170 lesions of varying histological risk (94 BBD and 76 CIS), and
in “normal” glands close to these lesions. The ERα level increased significantly in …
assaying, in benign breast disease (BBD) and in situ carcinomas (CIS), 2 markers, the
estrogen receptor α (ERα) and cathepsin D (cath-D) involved in estrogen action on
mammary tissue. ERα and cath-D were assayed by quantitative immunohistochemistry
using an image analyzer in 170 lesions of varying histological risk (94 BBD and 76 CIS), and
in “normal” glands close to these lesions. The ERα level increased significantly in …