Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency

Y Chen, Y Hu, G Moiseyev, KK Zhou, D Chen… - Microvascular …, 2009 - Elsevier
Our previous studies have shown that very low-density lipoprotein receptor (VLDLR) is a
negative regulator of the Wnt pathway. The present study showed that VLDLR gene
knockout (Vldlr−/−) mice displayed impaired cone ERG responses at early ages.
Immunostaining of mid-wavelength cones showed significantly decreased cone densities in
the retina and shortened cone outer segments in Vldlr−/− mice. At older ages, Vldlr−/− mice
displayed declined rod ERG responses, decreased layers of photoreceptor nuclei, reduced …