Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina

JW Lee, H Fuda, NB Javitt, CA Strott… - Experimental eye …, 2006 - Elsevier
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate
specificity for C27 sterols including 7-ketocholesterol (7kCh). CYP27A1 is widely expressed
in human tissues but has not been previously demonstrated in the retina. In this study, we
examined the expression and localization of CYP27A1 in the monkey retina where it
localized mainly to the photoreceptor inner segments. CYP27A1 was also observed in
Müller cells with faint immuno staining detected in the RPE and choriocapillaris. We also …