Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

SI Grivennikov, M Karin - Annals of the rheumatic diseases, 2011 - ard.bmj.com
Annals of the rheumatic diseases, 2011ard.bmj.com
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all,
solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour
initiation, growth and progression and many of these effects are mediated by
proinflammatory cytokines. Among these cytokines, the pro-tumourogenic function of tumour
necrosis factor (TNF) and interleukin 6 (IL-6) is well established. The role of TNF and IL-6 as
master regulators of tumour-associated inflammation and tumourigenesis makes them …
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all, solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour initiation, growth and progression and many of these effects are mediated by proinflammatory cytokines. Among these cytokines, the pro-tumourogenic function of tumour necrosis factor (TNF) and interleukin 6 (IL-6) is well established. The role of TNF and IL-6 as master regulators of tumour-associated inflammation and tumourigenesis makes them attractive targets for adjuvant treatment in cancer
ard.bmj.com