Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model
N Shindo, T Fujisawa, K Sugimoto, K Nojima… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is currently recognized as
a global health issue and encompasses a wide spectrum of entities, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis (NASH). The lack of a spontaneous animal
model of NASH, however, has hampered basic research in this field. METHODS: We
examined the hepatic lesions in the inbred Fatty Liver Shionogi (FLS) mouse, which exhibits
type 2 diabetes, and investigated the molecular mechanism leading to NAFLD/NASH. Using …
a global health issue and encompasses a wide spectrum of entities, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis (NASH). The lack of a spontaneous animal
model of NASH, however, has hampered basic research in this field. METHODS: We
examined the hepatic lesions in the inbred Fatty Liver Shionogi (FLS) mouse, which exhibits
type 2 diabetes, and investigated the molecular mechanism leading to NAFLD/NASH. Using …