MCM proteins: DNA damage, mutagenesis and repair
JM Bailis, SL Forsburg - Current opinion in genetics & development, 2004 - Elsevier
JM Bailis, SL Forsburg
Current opinion in genetics & development, 2004•ElsevierThe MCM2-7 complex, which may act as a replicative helicase during DNA synthesis, plays
a central role in S-phase genome stability. MCM proteins are required for processive DNA
replication and are a target of S-phase checkpoints. Loss of MCM function causes DNA
damage and genome instability. MCM expression is upregulated in proliferating cells,
providing a diagnostic marker for both cancerous cells and cells with the potential to become
malignant. The role of the MCM complex in genome integrity reflects its activity both at active …
a central role in S-phase genome stability. MCM proteins are required for processive DNA
replication and are a target of S-phase checkpoints. Loss of MCM function causes DNA
damage and genome instability. MCM expression is upregulated in proliferating cells,
providing a diagnostic marker for both cancerous cells and cells with the potential to become
malignant. The role of the MCM complex in genome integrity reflects its activity both at active …
The MCM2-7 complex, which may act as a replicative helicase during DNA synthesis, plays a central role in S-phase genome stability. MCM proteins are required for processive DNA replication and are a target of S-phase checkpoints. Loss of MCM function causes DNA damage and genome instability. MCM expression is upregulated in proliferating cells, providing a diagnostic marker for both cancerous cells and cells with the potential to become malignant. The role of the MCM complex in genome integrity reflects its activity both at active replication forks and away from forks.
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