Antioxidants in the retinal pigment epithelium
DA Newsome, MV Miceli, MR Liles, DJ Tate Jr… - Progress in retinal and …, 1994 - Elsevier
DA Newsome, MV Miceli, MR Liles, DJ Tate Jr, PD Oliver
Progress in retinal and eye research, 1994•ElsevierThe retinal pigment epithelium (RPE), a neuroectodermally-derived monolayer, lies between
a highly vascularized choroid and the neural retina. On its basal surface, the RPE adheres to
Bruch's membrane, a complex extracellular matrix basement membrane with selective
permeability and barrier properties (Bruch, 1844; Wolfrum, 1908; Nakaizumi, 1964;
Nakaizumi et al., 1964; Hogan, 1965; Kanwar and Farquhar, 1979; Kanwar et al., 1980; Pino
and Essner, 1981; Pino et al., 1982). The luminal surface of the RPE lies in close association …
a highly vascularized choroid and the neural retina. On its basal surface, the RPE adheres to
Bruch's membrane, a complex extracellular matrix basement membrane with selective
permeability and barrier properties (Bruch, 1844; Wolfrum, 1908; Nakaizumi, 1964;
Nakaizumi et al., 1964; Hogan, 1965; Kanwar and Farquhar, 1979; Kanwar et al., 1980; Pino
and Essner, 1981; Pino et al., 1982). The luminal surface of the RPE lies in close association …
The retinal pigment epithelium (RPE), a neuroectodermally-derived monolayer, lies between a highly vascularized choroid and the neural retina. On its basal surface, the RPE adheres to Bruch's membrane, a complex extracellular matrix basement membrane with selective permeability and barrier properties (Bruch, 1844; Wolfrum, 1908; Nakaizumi, 1964; Nakaizumi et al., 1964; Hogan, 1965; Kanwar and Farquhar, 1979; Kanwar et al., 1980; Pino and Essner, 1981; Pino et al., 1982). The luminal surface of the RPE lies in close association with the photoreceptor outer segments of the retina. Some of the essential functions of the RPE are summarized in Table 1. This metabolically active complex exists in an oxygen-rich environment. Reactive oxygen intermediate species occur naturally in oxygen-contain-
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