[HTML][HTML] Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
J Huang, Q Zhao, SM Mooney, FS Lee - Journal of Biological Chemistry, 2002 - ASBMB
Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia.
Under normoxic conditions, site-specific proline hydroxylation of the α subunits of HIF allows
recognition by the von Hippel-Lindau tumor suppressor protein (VHL), a component of an E3
ubiquitin ligase complex that targets these subunits for degradation by the ubiquitin-
proteasome pathway. Under hypoxic conditions, this hydroxylation is inhibited, allowing the
α subunits of HIF to escape VHL-mediated degradation. Three enzymes, prolyl hydroxylase …
Under normoxic conditions, site-specific proline hydroxylation of the α subunits of HIF allows
recognition by the von Hippel-Lindau tumor suppressor protein (VHL), a component of an E3
ubiquitin ligase complex that targets these subunits for degradation by the ubiquitin-
proteasome pathway. Under hypoxic conditions, this hydroxylation is inhibited, allowing the
α subunits of HIF to escape VHL-mediated degradation. Three enzymes, prolyl hydroxylase …