[HTML][HTML] CCAAT/enhancer-binding protein α mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase
L Qiao, OA MacDougald, J Shao - Journal of Biological Chemistry, 2006 - ASBMB
Excessive hepatic gluconeogenesis and glucose production are important contributors to
hyperglycemia in both type 1 and type 2 diabetes. In diabetic humans and animal models,
elevated levels of p38 mitogen-activated protein kinase (p38) are observed in several
tissues. Our study shows that activity of p38 is significantly elevated in livers of db/db or
streptozocin-induced type 1 diabetic mice. Using cultured hepatoma cells, we find that
activation of p38 enhances expression of hepatic gluconeogenic gene …
hyperglycemia in both type 1 and type 2 diabetes. In diabetic humans and animal models,
elevated levels of p38 mitogen-activated protein kinase (p38) are observed in several
tissues. Our study shows that activity of p38 is significantly elevated in livers of db/db or
streptozocin-induced type 1 diabetic mice. Using cultured hepatoma cells, we find that
activation of p38 enhances expression of hepatic gluconeogenic gene …