[HTML][HTML] Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses
G Fontemaggi, I Kela, N Amariglio, G Rechavi… - Journal of Biological …, 2002 - ASBMB
The newly discovered p53 family member, p73, has a striking homology to p53 in both
sequence and modular structure. Ectopic expression of p73 promotes transcription of p53
target genes and recapitulates the most characterized p53 biological effects such as growth
arrest, apoptosis, and differentiation. Unlike p53-deficient mice that develop normally but are
subject to spontaneous tumor formation, p73-deficient mice exhibit severe defects in the
development of central nervous system and suffer from inflammation but are not prone to …
sequence and modular structure. Ectopic expression of p73 promotes transcription of p53
target genes and recapitulates the most characterized p53 biological effects such as growth
arrest, apoptosis, and differentiation. Unlike p53-deficient mice that develop normally but are
subject to spontaneous tumor formation, p73-deficient mice exhibit severe defects in the
development of central nervous system and suffer from inflammation but are not prone to …