[HTML][HTML] Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase
J Seoane, AM Gómez-Foix, RM O'Doherty… - Journal of Biological …, 1996 - ASBMB
In a previous study (O'Doherty, RM, Lehman, DL, Seoane, J., Gómez-Foix, AM, Guinovart,
JJ, and Newgard, CB (1996) J. Biol. Chem. 271, 20524-20530), we demonstrated that
adenovirus-mediated overexpression of glucokinase but not hexokinase I has a potent
enhancing effect on glycogen synthesis in primary hepatocytes. In an effort to understand
the underlying mechanism of this differential effect of the two hexokinase isoforms, we have
investigated changes in key intracellular metabolites and the activation state of glycogen …
JJ, and Newgard, CB (1996) J. Biol. Chem. 271, 20524-20530), we demonstrated that
adenovirus-mediated overexpression of glucokinase but not hexokinase I has a potent
enhancing effect on glycogen synthesis in primary hepatocytes. In an effort to understand
the underlying mechanism of this differential effect of the two hexokinase isoforms, we have
investigated changes in key intracellular metabolites and the activation state of glycogen …