Besides its well established role in control of cellular cholesterol homeostasis, the liver X
receptor (LXR) has been implicated in the regulation of hepatic gluconeogenesis. We
investigated the role of the major hepatic LXR isoform in hepatic glucose metabolism during
the feeding-to-fasting transition in vivo. In addition, we explored hepatic glucose sensing by
LXR during carbohydrate refeeding. Lxrα-/-mice and their wild-type littermates were
subjected to a fasting-refeeding protocol and hepatic carbohydrate fluxes as well as whole …