[HTML][HTML] Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation
SF Evans, K Irmady, K Ostrow, T Kim, A Nykjaer… - Journal of Biological …, 2011 - ASBMB
Brain-derived neurotrophic factor (BDNF) regulates neuronal differentiation, synaptic
plasticity, and morphology, and modest changes in BDNF levels results in complex
behavioral phenotypes. BDNF levels and intracellular localization in neurons are regulated
by multiple mechanisms, including use of distinct promoters, mRNA and protein transport,
and regulated cleavage of proBDNF to mature BDNF. Sortilin is an intracellular chaperone
that binds to the prodomain of BDNF to traffic it to the regulated secretory pathway. However …
plasticity, and morphology, and modest changes in BDNF levels results in complex
behavioral phenotypes. BDNF levels and intracellular localization in neurons are regulated
by multiple mechanisms, including use of distinct promoters, mRNA and protein transport,
and regulated cleavage of proBDNF to mature BDNF. Sortilin is an intracellular chaperone
that binds to the prodomain of BDNF to traffic it to the regulated secretory pathway. However …