Chronic pain is a debilitating clinical condition associated with a variety of disease entities
including diabetic neuropathy, postherpetic neuralgia, low back pathology, fibromyalgia, and
neurological disorders. For many general practitioners and specialists, managing chronic
pain has become a daunting challenge. As a modality of multidisciplinary chronic pain
management, medications are often prescribed in combinations, an approach referred to as
combination drug therapy (CDT). However, many medications for pain therapy, including …