Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta
S Thuret, L Bhatt, DDM O'Leary, HH Simon - Molecular and Cellular …, 2004 - Elsevier
The hallmark of Parkinson's Disease is the degenerative loss of mesencephalic
dopaminergic (mDA) neurons. Previous studies have shown that the homeobox transcription
factors, engrailed-1 and-2, are essential for the survival of these cells. To identify genes
downstream of engrailed-1 and-2, we performed a PCR-based differential display,
comparing RNA from engrailed-1/2 double mutant and wild type ventral midbrain of different
embryonic ages to adult olfactory bulb, a source of unrelated DA neurons. Here, we report …
dopaminergic (mDA) neurons. Previous studies have shown that the homeobox transcription
factors, engrailed-1 and-2, are essential for the survival of these cells. To identify genes
downstream of engrailed-1 and-2, we performed a PCR-based differential display,
comparing RNA from engrailed-1/2 double mutant and wild type ventral midbrain of different
embryonic ages to adult olfactory bulb, a source of unrelated DA neurons. Here, we report …