[HTML][HTML] Interleukin-1β decreases expression of the epithelial sodium channel α-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway
Acute lung injury (ALI) is a devastating syndrome characterized by diffuse alveolar damage,
elevated airspace levels of pro-inflammatory cytokines, and flooding of the alveolar spaces
with protein-rich edema fluid. Interleukin-1β (IL-1β) is one of the most biologically active
cytokines in the distal airspaces of patients with ALI. IL-1β has been shown to increase lung
epithelial and endothelial permeability. In this study, we hypothesized that IL-1β would
decrease vectorial ion and water transport across the distal lung epithelium. Therefore, we …
elevated airspace levels of pro-inflammatory cytokines, and flooding of the alveolar spaces
with protein-rich edema fluid. Interleukin-1β (IL-1β) is one of the most biologically active
cytokines in the distal airspaces of patients with ALI. IL-1β has been shown to increase lung
epithelial and endothelial permeability. In this study, we hypothesized that IL-1β would
decrease vectorial ion and water transport across the distal lung epithelium. Therefore, we …