Enteral omega-3 fatty acid, γ-linolenic acid, and antioxidant supplementation in acute lung injury

TW Rice, AP Wheeler, BT Thompson, BP DeBoisblanc… - Jama, 2011 - jamanetwork.com
Context The omega-3 (n-3) fatty acids docosahexaenoic acid and eicosapentaenoic acid,
along with γ-linolenic acid and antioxidants, may modulate systemic inflammatory response
and improve oxygenation and outcomes in patients with acute lung injury. Objective To
determine if dietary supplementation of these substances to patients with acute lung injury
would increase ventilator-free days to study day 28. Design, Setting, and Participants The
OMEGA study, a randomized, double-blind, placebo-controlled, multicenter trial conducted …