Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
PE Parsons, MD Eisner, BT Thompson… - Critical care …, 2005 - journals.lww.com
Objectives: To evaluate the association between interleukin-6, interleukin-8, and interleukin-
10 and clinical outcomes including mortality in patients with acute lung injury and to
determine whether lower tidal volume ventilation was associated with a decrease in plasma
cytokines in patients with acute lung injury. Design: Multiple-center, randomized trial.
Setting: Intensive care units in ten university centers. Patients: The study included 861
patients enrolled in the National Heart, Lung and Blood Institute Acute Respiratory Distress …
10 and clinical outcomes including mortality in patients with acute lung injury and to
determine whether lower tidal volume ventilation was associated with a decrease in plasma
cytokines in patients with acute lung injury. Design: Multiple-center, randomized trial.
Setting: Intensive care units in ten university centers. Patients: The study included 861
patients enrolled in the National Heart, Lung and Blood Institute Acute Respiratory Distress …