HHV-8 and EBV are not commonly found in idiopathic pulmonary fibrosis.
Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of …, 2005•europepmc.org
Methods We used a variety of sensitive technologies including immunohistochemistry with
NCL-HHV8-LNA and EBV-LMP1 antibodies, as well as of EBV RNA (EBER) by in-situ
hybridisation; the presence of HHV-8 and EBV DNA was also investigated by means of PCR
and subsequent analysis using a microfluidic apparatus. Results Despite the good sample
quality, immunohistochemical, in-situ hybridisation and PCR results were negative for both
EBV and HHV-8. Conclusions We conclude that EBV and HHV-8 are not involved in the …
NCL-HHV8-LNA and EBV-LMP1 antibodies, as well as of EBV RNA (EBER) by in-situ
hybridisation; the presence of HHV-8 and EBV DNA was also investigated by means of PCR
and subsequent analysis using a microfluidic apparatus. Results Despite the good sample
quality, immunohistochemical, in-situ hybridisation and PCR results were negative for both
EBV and HHV-8. Conclusions We conclude that EBV and HHV-8 are not involved in the …
Methods
We used a variety of sensitive technologies including immunohistochemistry with NCL-HHV8-LNA and EBV-LMP1 antibodies, as well as of EBV RNA (EBER) by in-situ hybridisation; the presence of HHV-8 and EBV DNA was also investigated by means of PCR and subsequent analysis using a microfluidic apparatus.
Results
Despite the good sample quality, immunohistochemical, in-situ hybridisation and PCR results were negative for both EBV and HHV-8.
Conclusions
We conclude that EBV and HHV-8 are not involved in the pathogenesis of IPF/UIP.
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