[HTML][HTML] Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor α-converting enzyme and amphiregulin
H Lemjabbar, D Li, M Gallup, S Sidhu, E Drori… - Journal of Biological …, 2003 - ASBMB
Cells dividing at the time of carcinogen exposure are at particular risk for neoplasia.
Tobacco smoke contains numerous carcinogens, and we find that smoke, in the absence of
exogenous growth factors, is capable of stimulating cell proliferation. The smoke-triggered
mechanism includes the generation of oxygen radicals, which in turn stimulate tumor
necrosis factor α-converting enzyme (a disintegrin and metalloproteinase (ADAM) 17) to
cleave transmembrane amphiregulin, a ligand for the epidermal growth factor receptor …
Tobacco smoke contains numerous carcinogens, and we find that smoke, in the absence of
exogenous growth factors, is capable of stimulating cell proliferation. The smoke-triggered
mechanism includes the generation of oxygen radicals, which in turn stimulate tumor
necrosis factor α-converting enzyme (a disintegrin and metalloproteinase (ADAM) 17) to
cleave transmembrane amphiregulin, a ligand for the epidermal growth factor receptor …