Transformation of alveolar type 2 cells to type 1 cells following exposure to NO2
MJ Evans, LJ Cabral, RJ Stephens… - … and molecular pathology, 1975 - Elsevier
This research was undertaken to study the fate of Type 2 cells after they have divided. To
accomplish this, male rats were exposed to NO 2 to increase the number of dividing Type 2
cells. Dividing cells were labeled with 3 H-TdR and studied with autoradiographic
techniques in the electron microscope for up to 14 days after labeling. The results show that
initially most of the 3 H-TdR labeled cells were Type 2. However, by 2 days there was a
decrease in frequency of labeled Type 2 cells and a large increase in labeled Type 1 cells …
accomplish this, male rats were exposed to NO 2 to increase the number of dividing Type 2
cells. Dividing cells were labeled with 3 H-TdR and studied with autoradiographic
techniques in the electron microscope for up to 14 days after labeling. The results show that
initially most of the 3 H-TdR labeled cells were Type 2. However, by 2 days there was a
decrease in frequency of labeled Type 2 cells and a large increase in labeled Type 1 cells …