[HTML][HTML] S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)

T Arumugam, DM Simeone, AM Schmidt… - Journal of Biological …, 2004 - ASBMB
S100P is a member of the S100 protein family that is expressed in several malignant
neoplasms. Currently the effects of this molecule on cell function are unknown. In the
present study we investigated the biological effects and mechanisms of action of S100P
using NIH3T3 cells. Expression of S100P in NIH3T3 cells led to the presence of S100P in
the culture medium, increased cellular proliferation, and enhanced survival after detachment
from the culture substrate or after exposure to the chemotherapeutic agent 5-flurouracil. The …