Heat-shock proteins induce T-cell regulation of chronic inflammation

W Van Eden, R Van der Zee, B Prakken - Nature Reviews Immunology, 2005 - nature.com
Nature Reviews Immunology, 2005nature.com
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In
experimental disease models, HSPs can prevent or arrest inflammatory damage, and in
initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides
have been shown to promote the production of anti-inflammatory cytokines, indicating that
HSPs have immunoregulatory potential. In this Review, we discuss the unique …
Abstract
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, HSPs can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory disease, HSP-derived peptides have been shown to promote the production of anti-inflammatory cytokines, indicating that HSPs have immunoregulatory potential. In this Review, we discuss the unique characteristics of HSPs that endow them with these immunoregulatory qualities.
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