The alarmin functions of high-mobility group proteins

D Yang, P Tewary, G de la Rosa, F Wei… - … et Biophysica Acta (BBA …, 2010 - Elsevier
D Yang, P Tewary, G de la Rosa, F Wei, JJ Oppenheim
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 2010Elsevier
High-mobility group (HMG) proteins are non-histone nuclear proteins that bind nucleosomes
and regulate chromosome architecture and gene transcription. Over the past decade,
numerous studies have established that some HMG proteins can be released extracellularly
and demonstrate distinct extracellular biological activities. Here, we will give a brief overview
of HMG proteins and highlight their participation in innate/inflammatory and adaptive
immune responses. They have the activities of alarmins, which are endogenous mediators …
High-mobility group (HMG) proteins are non-histone nuclear proteins that bind nucleosomes and regulate chromosome architecture and gene transcription. Over the past decade, numerous studies have established that some HMG proteins can be released extracellularly and demonstrate distinct extracellular biological activities. Here, we will give a brief overview of HMG proteins and highlight their participation in innate/inflammatory and adaptive immune responses. They have the activities of alarmins, which are endogenous mediators that are rapidly released in response to danger signals initiated by infection and/or tissue damage and are capable of activating innate and adaptive immunity by promoting the recruitment and activation of antigen-presenting cells (APCs).
Elsevier