Methotrexate withdrawal at 6 vs 12 months in juvenile idiopathic arthritis in remission: a randomized clinical trial

D Foell, N Wulffraat, LR Wedderburn, H Wittkowski… - Jama, 2010 - jamanetwork.com
Context Novel therapies have improved the remission rate in chronic inflammatory disorders
including juvenile idiopathic arthritis (JIA). Therefore, strategies of tapering therapy and
reliable parameters for detecting subclinical inflammation have now become challenging
questions. Objectives To analyze whether longer methotrexate treatment during remission of
JIA prevents flares after withdrawal of medication and whether specific biomarkers identify
patients at risk for flares. Design, Setting, and Patients Prospective, open, multicenter …