Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
JE Gern, GD Brooks, P Meyer, A Chang, K Shen… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Viral infections are the major cause of acute wheezing illnesses in
childhood. Variations in immunologic responses at birth may be determinants of the risk of
acquiring these illnesses. OBJECTIVES: To determine the immunologic risk factors for virus-
induced wheezing in high-risk infants. METHODS: The study involves 285 children with a
parental history of asthma and/or respiratory allergies. Mononuclear cells obtained at birth
(umbilical cord blood) and at 1 year of age were incubated with phytohemagglutinin …
childhood. Variations in immunologic responses at birth may be determinants of the risk of
acquiring these illnesses. OBJECTIVES: To determine the immunologic risk factors for virus-
induced wheezing in high-risk infants. METHODS: The study involves 285 children with a
parental history of asthma and/or respiratory allergies. Mononuclear cells obtained at birth
(umbilical cord blood) and at 1 year of age were incubated with phytohemagglutinin …