[HTML][HTML] Modification of the Stat1 SH2 Domain Broadly Improves Interferon Efficacy in Proportion to p300/CREB-binding Protein Coactivator Recruitment*♦
Y Zhang, K Takami, MS Lo, G Huang, Q Yu… - Journal of Biological …, 2005 - ASBMB
A normal level of interferon (IFN) responsiveness via the Stat1 transcription factor is critical
to the host, since decreased Stat1 signaling causes immune compromise and increased
signaling is associated with inflammatory and neoplastic disease. Here we report how this
balance may be influenced by novel alterations in the efficiency of Stat1 signaling. To
enable disulfide-dependent and spontaneous formation of active Stat1 homodimer (as was
done previously for Stat3), we engineered Stat1-CC with double-cysteine substitutions in the …
to the host, since decreased Stat1 signaling causes immune compromise and increased
signaling is associated with inflammatory and neoplastic disease. Here we report how this
balance may be influenced by novel alterations in the efficiency of Stat1 signaling. To
enable disulfide-dependent and spontaneous formation of active Stat1 homodimer (as was
done previously for Stat3), we engineered Stat1-CC with double-cysteine substitutions in the …