Trypanosoma cruzi receptors for human transferrin and their role
MF Lima, F Villalta - Molecular and Biochemical Parasitology, 1990 - Elsevier
Trypanosoma cruzi amastigotes present receptors for human transferrin as indicated by the
saturable binding of 125 I-transferrin to this form of the parasite. Computerized Scatchard
analysis revealed one class of receptors present at 8.1× 10 4 receptors per amastigote with
a K d of 2.82 μM. Immunofluorescence studies indicate that more than 90% of amastigotes
bind human transferrin, whereas trypomastigotes do not. Iron is required for amastigote
growth in cell-free medium since deferoxamine, an iron chelator, inhibits amastigote growth …
saturable binding of 125 I-transferrin to this form of the parasite. Computerized Scatchard
analysis revealed one class of receptors present at 8.1× 10 4 receptors per amastigote with
a K d of 2.82 μM. Immunofluorescence studies indicate that more than 90% of amastigotes
bind human transferrin, whereas trypomastigotes do not. Iron is required for amastigote
growth in cell-free medium since deferoxamine, an iron chelator, inhibits amastigote growth …