Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition
C Zoccali, P Ruggenenti, A Perna… - Journal of the …, 2011 - journals.lww.com
Phosphate may promote the onset and progression of chronic nephropathies. Here we
evaluated the relationships between baseline serum phosphate levels, disease progression,
and response to ACE inhibition in 331 patients with proteinuric nephropathies in the
prospective Ramipril Efficacy In Nephropathy (REIN) trial. Independent of treatment, patients
with phosphate levels in the highest two quartiles progressed significantly faster either to
ESRD or to a composite endpoint of doubling of serum creatinine or ESRD compared with …
evaluated the relationships between baseline serum phosphate levels, disease progression,
and response to ACE inhibition in 331 patients with proteinuric nephropathies in the
prospective Ramipril Efficacy In Nephropathy (REIN) trial. Independent of treatment, patients
with phosphate levels in the highest two quartiles progressed significantly faster either to
ESRD or to a composite endpoint of doubling of serum creatinine or ESRD compared with …