Wnt is a family of secreted signaling proteins that regulate diverse developmental
processes. Activation of canonical Wnt signaling by Wnt10b inhibits differentiation of
preadipocytes in vitro. To determine whether Wnt signaling blocks adipogenesis in vivo, we
created transgenic mice in which Wnt10b is expressed from the FABP4 promoter.
Expression of Wnt10b in adipose impairs development of this tissue throughout the body,
with a decline of∼ 50% in total body fat and a reduction of∼ 60% in weight of epididymal …