[HTML][HTML] Induction of heme oxygenase-1 inhibits NAD (P) H oxidase activity by down-regulating cytochrome b558 expression via the reduction of heme availability
Heme-oxygenase-1 (HO-1), the rate-limiting enzyme of heme degradation, has powerful anti-
oxidant properties related to the production of the reactive oxygen species scavenger
bilirubin. However, some data suggest that HO-1 could also inhibit the cellular production of
reactive oxygen species. Therefore, we investigated whether the anti-oxidant properties of
HO-1 could be mediated by modulation of the activity and/or expression of the heme-
containing NAD (P) H oxidase, the main source of the superoxide anion ((O 2˙−)) in …
oxidant properties related to the production of the reactive oxygen species scavenger
bilirubin. However, some data suggest that HO-1 could also inhibit the cellular production of
reactive oxygen species. Therefore, we investigated whether the anti-oxidant properties of
HO-1 could be mediated by modulation of the activity and/or expression of the heme-
containing NAD (P) H oxidase, the main source of the superoxide anion ((O 2˙−)) in …