Role for p53 in gene induction by double-stranded RNA
BT Hummer, XL Li, BA Hassel - Journal of virology, 2001 - Am Soc Microbiol
BT Hummer, XL Li, BA Hassel
Journal of virology, 2001•Am Soc MicrobiolCross talk between p53 and interferon-regulated pathways is implicated in the induction of
gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-
stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction
by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in
the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.
gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-
stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction
by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in
the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.
Abstract
Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.
American Society for Microbiology