[HTML][HTML] Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3
O Malakhova, M Malakhov, C Hetherington… - Journal of Biological …, 2002 - ASBMB
UBP43 is a protease that specifically removes a ubiquitin-like protein, ISG15, from its targets.
Highest levels ofUBP43 expression are detected in macrophages and in cell lines of
monocytic lineage. Macrophages are important in host defense against bacterial and viral
infections. The lipopolysaccharide (LPS) of the bacterial cell wall can mimic bacteria and
activate monocytes/macrophages to provoke inflammatory responses. Here, we report that
LPS strongly activates UBP43 expression in macrophages, which is paralleled by changes …
Highest levels ofUBP43 expression are detected in macrophages and in cell lines of
monocytic lineage. Macrophages are important in host defense against bacterial and viral
infections. The lipopolysaccharide (LPS) of the bacterial cell wall can mimic bacteria and
activate monocytes/macrophages to provoke inflammatory responses. Here, we report that
LPS strongly activates UBP43 expression in macrophages, which is paralleled by changes …