Steroids are key factors in a myriad of mammalian biological systems, including the brain,
kidney, heart, bones, and gonads. While alternative potential steroid receptors have been
described, the majority of biologically relevant steroid responses appear to be mediated by
classical steroid receptors that are located in all parts of the cell, from the plasma membrane
to the nucleus. Interestingly, these classical steroid receptors modulate different signals
depending upon their location. For example, receptors in the plasma membrane interact with …