Corticosteroids and central serous chorioretinopathy

CA Carvalho-Recchia, LA Yannuzzi, S Negrão… - Ophthalmology, 2002 - Elsevier
CA Carvalho-Recchia, LA Yannuzzi, S Negrão, RF Spaide, KB Freund
Ophthalmology, 2002Elsevier
PURPOSE: The purpose of this study is to investigate the relationship between
corticosteroid use and central serous chorioretinopathy (CSC). DESIGN: A prospective, case-
controlled study. PARTICIPANTS AND CONTROLS: A consecutive series of patients with
acute manifestations of CSC and a control group matched for age, race, and gender were
recruited between January 2000 and July 2000. METHODS: A detailed clinical history was
taken, and fundus examination with slit-lamp biomicroscopy was performed on all patients …
PURPOSE
The purpose of this study is to investigate the relationship between corticosteroid use and central serous chorioretinopathy (CSC).
DESIGN
A prospective, case-controlled study.
PARTICIPANTS AND CONTROLS
A consecutive series of patients with acute manifestations of CSC and a control group matched for age, race, and gender were recruited between January 2000 and July 2000.
METHODS
A detailed clinical history was taken, and fundus examination with slit-lamp biomicroscopy was performed on all patients. Fluorescein angiography was obtained on the study patients.
RESULTS
A total of 50 patients was recruited. Twenty-six patients (52%) had a history of exogenous steroid use, including oral, intravenous, intranasal, and intraarticular administration. Two additional patients had a history of endogenous hypercortisolism (Cushing’s syndrome). In a matched control group, eight patients (18%) had a history of steroid use. The difference in corticosteroid exposure between study patients and controls was statistically significant (P < 0.0001).
MAIN OUTCOME MEASURES
History of corticosteroid use or Cushing’s syndrome.
CONCLUSIONS
This study is consistent with previous reports associating steroid use with CSC. It identifies corticosteroids as a significant risk factor for the development of acute, exudative macular manifestation and implicates hypercortisolism as a factor in the pathogenesis of this disorder. Several forms of corticosteroid administration were observed to be a risk factor for CSC. Accordingly, susceptible patients in need of corticosteroids should be advised of the risk of developing acute manifestations of CSC.
Elsevier