Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity
MJ Smyth, GP Dunn, RD Schreiber - Advances in immunology, 2006 - Elsevier
Cellular transformation and tumor development result from an accumulation of mutational
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100
years, there has been a vigorous debate as to whether the unmanipulated immune system
can detect and eliminate such altered host derived cells despite the fact that cancer cells
frequently express either abnormal proteins or abnormal levels of normal cellular proteins
that function as tumor antigens. In this review, we discuss the current state of this argument …
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100
years, there has been a vigorous debate as to whether the unmanipulated immune system
can detect and eliminate such altered host derived cells despite the fact that cancer cells
frequently express either abnormal proteins or abnormal levels of normal cellular proteins
that function as tumor antigens. In this review, we discuss the current state of this argument …