[HTML][HTML] Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids

RH Oakley, JA Cidlowski - Journal of Biological Chemistry, 2011 - ASBMB
Glucocorticoids regulate numerous physiological processes and are mainstays in the
treatment of inflammation, autoimmune disease, and cancer. The traditional view that
glucocorticoids act through a single glucocorticoid receptor (GR) protein has changed in
recent years with the discovery of a large cohort of receptor subtypes arising from alternative
processing of the GR gene. These isoforms differ in their expression, gene regulatory, and
functional profiles. Post-translational modification of these proteins further expands GR …