The link between intra-abdominal adiposity and type II diabetes has been known for
decades, and adipose tissue macrophage (ATM)-associated inflammation has recently been
linked to insulin resistance. However, the mechanisms associated with ATM recruitment
remain ill defined. Herein, we describe in vitro chemotaxis studies, in which adipocyte
conditioned medium was used to stimulate macrophage migration. We demonstrate that
tumor necrosis factor α and free fatty acids, key inflammatory stimuli involved in obesity …