Experimental allergic encephalomyelitis in the rat is inhibited by aminoguanidine, an inhibitor of nitric oxide synthase
W Zhao, RG Tilton, JA Corbett, ML McDaniel… - Journal of …, 1996 - Elsevier
This study assessed the role of de novo nitric oxide (NO) production in the pathogenesis of
experimental allergic encephalomyelitis (EAE) by using aminoguanidine (AG), an inhibitor of
nitric oxide synthase (NOS). which preferentially inhibits the cytokine-and endotoxin-
inducible isoform of NOS versus the constitutive isoforms consisting of endothelial and
neuronal NOS. The maximum clinical severity of EAE and the duration of illness were
significantly reduced or totally inhibited by twice daily subcutaneous injection of 100 mg/kg …
experimental allergic encephalomyelitis (EAE) by using aminoguanidine (AG), an inhibitor of
nitric oxide synthase (NOS). which preferentially inhibits the cytokine-and endotoxin-
inducible isoform of NOS versus the constitutive isoforms consisting of endothelial and
neuronal NOS. The maximum clinical severity of EAE and the duration of illness were
significantly reduced or totally inhibited by twice daily subcutaneous injection of 100 mg/kg …