[HTML][HTML] RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway
F Wang, M Yamauchi, M Muramatsu, T Osawa… - Journal of biological …, 2011 - ASBMB
Vascular endothelial growth factor (VEGF) is vital to physiological as well as pathological
angiogenesis, and regulates a variety of cellular functions, largely by activating its 2
receptors, fms-like tyrosine kinase (Flt1) and kinase domain receptor (KDR). KDR plays a
critical role in the proliferation of endothelial cells by controlling VEGF-induced
phospholipase Cγ-protein kinase C (PLCγ-PKC) signaling. The function of Flt1, however,
remains to be clarified. Recent evidence has indicated that Flt1 regulates the VEGF …
angiogenesis, and regulates a variety of cellular functions, largely by activating its 2
receptors, fms-like tyrosine kinase (Flt1) and kinase domain receptor (KDR). KDR plays a
critical role in the proliferation of endothelial cells by controlling VEGF-induced
phospholipase Cγ-protein kinase C (PLCγ-PKC) signaling. The function of Flt1, however,
remains to be clarified. Recent evidence has indicated that Flt1 regulates the VEGF …