[HTML][HTML] Cpc2/RACK1 is a ribosome-associated protein that promotes efficient translation in Schizosaccharomyces pombe

B Shor, J Calaycay, J Rushbrook, M McLeod - Journal of Biological …, 2003 - ASBMB
Cpc2/RACK1 is a highly conserved WD domain protein found in all eucaryotes.
Cpc2/RACK1 functions on mammalian signal transduction pathways most notably as an
adaptor protein for the βII protein kinase C isozyme. In single cell eucaryotes, Cpc2/RACK1
regulates growth, differentiation, and entry into G 0 stationary phase. The exact biochemical
function of Cpc2/RACK1 is unknown. Here, we provide evidence that Cpc2 is associated
with the ribosome. Using immunoaffinity purification, we isolated ribosomal proteins in …