The primary cilium as a cellular signaling center: lessons from disease
MA Lancaster, JG Gleeson - Current opinion in genetics & development, 2009 - Elsevier
Current opinion in genetics & development, 2009•Elsevier
Genetic diseases known as ciliopathies have recently entered the limelight, placing new
importance on a previously mysterious organelle: the primary cilium. Mutations affecting the
primary cilium in both humans and animal models can lead to a plethora of distinct
phenotypes including retinal degeneration, kidney cysts, and brain malformations. New
findings are quickly lending insight into the functions of this cellular extension that seems to
be especially important in modulation of subcellular signaling cascades at various stages of …
importance on a previously mysterious organelle: the primary cilium. Mutations affecting the
primary cilium in both humans and animal models can lead to a plethora of distinct
phenotypes including retinal degeneration, kidney cysts, and brain malformations. New
findings are quickly lending insight into the functions of this cellular extension that seems to
be especially important in modulation of subcellular signaling cascades at various stages of …
Genetic diseases known as ciliopathies have recently entered the limelight, placing new importance on a previously mysterious organelle: the primary cilium. Mutations affecting the primary cilium in both humans and animal models can lead to a plethora of distinct phenotypes including retinal degeneration, kidney cysts, and brain malformations. New findings are quickly lending insight into the functions of this cellular extension that seems to be especially important in modulation of subcellular signaling cascades at various stages of development and adult homeostasis.
Elsevier