Diamond Blackfan anemia (DBA) is a rare congenital anemia, with more than 50% of
patients having mutations in a ribosomal protein. Evidence suggests that both translation
and p53 activation play roles in mediating the hematopoietic phenotype. The reason for
erythroid specificity of DBA is unclear. Several zebrafish models of DBA have been
generated, and these models have already provided key information about disease
pathogenesis. The zebrafish model is particularly amenable for studying blood …